@misc{10481/59869,
year = {2019},
url = {http://hdl.handle.net/10481/59869},
abstract = {Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational
importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports the
development, full scope, and a mechanistic picture for a strikingly different way of forging such functional groups. Thus,
carboxylic acids, once converted to redox-active esters (RAEs) can be utilized as formally nucleophilic coupling partners with
other carboxylic derivatives (to produce ketones), imines (to produce benzylic amines), or aldehydes (to produce alcohols).
The reactions are uniformly mild, operationally simple, and, in the case of ketone synthesis, broad in scope (including several
applications to the simplification of synthetic problems and to parallel synthesis). Finally, an extensive mechanistic study of
the ketone synthesis is performed to trace the elementary steps of the catalytic cycle and provide the end-user with a clear
and understandable rationale for the selectivity, role of additives, and underlying driving forces involved.},
organization = {Financial support for this work was provided by NIH (GM-
118176), the China Scholarship Council (CSC, S.N.), the Marie
Skłodowska-Curie Global Fellowships (749359-EnanSET,
N.M.P) within the European Union research and innovation
framework programme (2014-2020), and the fulbright Scholar
Program (P.K.M.).},
publisher = {American Chemical Society},
title = {A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines},
doi = {10.1021/jacs.9b02238},
author = {Ni, Shengyang and Muñoz Padial, Natalia},
}