@misc{10481/59813,
year = {2019},
month = {2},
url = {http://hdl.handle.net/10481/59813},
abstract = {Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain,
even in morphine-tolerant animals. However, it is unknown whether these receptors
are able to modulate morphine antinociception and tolerance during inflammatory pain.
Here we used a mouse model to test the modulation of morphine effects by the
selective sigma-1 antagonist S1RA (MR309), by determining its effect on inflammatory
tactile allodynia (von Frey filaments) and on grip strength deficits induced by joint
inflammation (a measure of pain-induced functional disability), and compared the results
with those for nociceptive heat pain recorded with the unilateral hot plate (55 C) test.
The subcutaneous (s.c.) administration of morphine induced antinociceptive effects
to heat stimuli, and restored mechanical threshold and grip strength in mice with
periarticular inflammation induced by Complete Freund’s Adjuvant. S1RA (80 mg/kg,
s.c.) administered alone did not induce any effect on nociceptive heat pain or
inflammatory allodynia, but was able to partially reverse grip strength deficits. The
association of S1RA with morphine, at doses inducing little or no analgesic-like effects
when administered alone, resulted in a marked antinociceptive effect to heat stimuli
and complete reversion of inflammatory tactile allodynia. However, S1RA administration
did not increase the effect of morphine on grip strength deficits induced by joint
inflammation.},
organization = {MT was supported by a postdoctoral grant from the University of
Granada.MR-C and IB-C were supported by FPU grants from the
Spanish Ministry of Economy and Competitiveness (MINECO).
This study was partially supported by the Spanish Ministry of
Economy and Competitiveness (Grants SAF2013-47481P and
SAF2016-80540-R), the Junta de Andalucía (Grant CTS109), and
FEDER funds.},
publisher = {Frontiers Media},
keywords = {Sigma-1 receptors},
keywords = {Morphine},
keywords = {Analgesia},
keywords = {Joint inflammation},
keywords = {Grip strength},
title = {Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation},
doi = {10.3389/fphar.2019.00136},
author = {Montilla-García, Ángeles and Tejada, Miguel Ángel and Ruiz Cantero, María del Carmen and Bravo Caparrós, Inmaculada and Yeste, Sandra and Zamanillo, Daniel and Cobos del Moral, Enrique José},
}