@misc{10481/59670,
year = {2019},
url = {http://hdl.handle.net/10481/59670},
abstract = {Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been
widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. We carried out a population-based case–control study including 1513 incident cases of breast cancer,
1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to
alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered
different scenarios of exposure and different subtypes of alkylphenolic compounds.
Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast
cancer (OR=1.23; 95% CI=1.01–1.48). Within the different scenarios, the occupational use of domestic
tensioactives was positively associated with breast cancer (OR=1.28; 95% CI=1.02–1.60), while occupational
exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol
ethoxylates was positively associated with breast cancer (OR=1.21; 95% CI=1.00–1.47), while
exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic
compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic,
hair and personal hygiene products. Our findings suggest a modest association between breast cancer risk and occupational exposure to
alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings
warrant further corroboration in other studies.},
organization = {This work was partially funded by the public grants from the
Catalan Government (2014SGR756, 2017SGR1085, 2017SGR733,
SLT006/17/76), and European Regional Development Fund-ERDF, by
the “Accion Transversal del Cancer”, approved on the Spanish Ministry
Council on the 11th October 2007, by the Instituto de Salud Carlos IIIFEDER
(PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria,
PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/
01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/
01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/
00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/
00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/
00049, PI17/01179), by the Fundación Marqués de Valdecilla (API 10/
09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII
(RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), by
the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-
0306-2011, salud201200057018tra), by the Conselleria de Sanitat of
the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP
00310), by the Regional Government of the Basque Country, by the
Consejería de Sanidad de la Región de Murcia, by the European
Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish
Association Against Cancer (AECC) Scientific Foundation, by the
Catalan Government-Agency for Management of University and
Research Grants (AGAUR) grants 2014SGR647 and 2014SGR850.
ISGlobal is a member of the CERCA Programme, Generalitat de
Catalunya.},
publisher = {Elsevier BV},
keywords = {Alkylphenols},
keywords = {Alkylphenolic compounds},
keywords = {Job-exposure matrix},
keywords = {Breast cancer},
keywords = {Prostate cancer},
keywords = {Occupational exposure},
title = {Alkylphenolic compounds and risk of breast and prostate cancer in the MCCSpain study},
doi = {10.1016/j.envint.2018.12.007},
author = {Jiménez Moleón, José Juan},
}