@misc{10481/59579,
year = {2020},
url = {http://hdl.handle.net/10481/59579},
abstract = {Mango consumption has shown bioactive properties against several diseases like diabetes, therefore, we evaluated
how a mango-supplemented diet affects metabolic pathways in diabetic rats. Serum and liver samples were
collected from 26 rats divided into 3 groups (healthy, untreated diabetic and mango-treated diabetic) after
dietary intervention and analysed using an LC-MS untargeted metabolomic strategy. Twenty-six and 29 metabolites
in serum and liver were potentially annotated, showing significant differences among groups. Several
affected pathways were due to the disease state [fatty acids (i.e. palmitoleic, linolenic, stearidonic, eicosapentaenoic,
docosahexaenoic acids and others), bile acids (i.e. glycocholic acid) and amino acids (i.e. leucine,
isoleucine and valine)], and others due to mango supplementation (increased hepatic bioaccumulation of euxanthone,
a mangiferin metabolite, and increased glutathione concentration). These results suggest that a
mango-supplemented diet exerted a significant antioxidant effect in the liver of diabetic rats, likely due to its
phenolic compounds, like mangiferin and its metabolites.},
organization = {The author AFO received support from the Spanish Ministry of
Education, Culture and Sports (FPU grant 14/03992). RCC is thankful
to CIAD-CONACYT for the scholarship received. We thank CONACYTMexico
for financial support of the project Ciencia de la Frontera
(P00054044). This study is considered as part of the collaboration that
ASC and GAG have in the network (ALSUB-CYTED, 118RT0543).},
publisher = {Elsevier BV},
keywords = {'Ataulfo’ mango},
keywords = {Mangifera indica L},
keywords = {Diabetes mellitus},
keywords = {Metabolomics},
keywords = {Mass spectrometry},
title = {Evaluation of metabolic changes in liver and serum of streptozotocininduced diabetic rats after Mango diet supplementation},
doi = {10.1016/j.jff.2019.103695},
author = {Fernández Ochoa, Álvaro and Cázares Camacho, Rosario and Borras Linares, María Isabel and Domínguez Ávila, J. Abraham and Segura Carretero, Antonio and González Aguilar, Gustavo Adolfo},
}