@misc{10481/59498,
year = {2019},
url = {http://hdl.handle.net/10481/59498},
abstract = {Hyaluronic acid (HA), as one of the main components of the extracellular matrix (ECM), plays a significant role
in a multitude of biological processes involving cell migration, proliferation, differentiation, wound healing
and inflammation. Thanks to its excellent biocompatibility, biodegradability and hygroscopic properties, HA
has been used in its natural form for joint lubrication and ocular treatment. The chemical structure of HA
can be easily modified by direct reaction with its carboxyl and hydroxyl groups. Recently, HA derivatives
have been synthesised with the aim of developing HA-based materials with increased mechanical strength,
improved cell interactions and reduced biodegradation and studied for regenerative medicine purposes,
including cell therapy and tissue engineering. In this context, the present manuscript reviews HA applications
from a basic point of view – including chemical modifications and cellular biology aspects related to clinical
translation – and future perspectives of using biofabrication technologies for regenerative medicine. A detailed
description of current clinical trials, testing advanced therapies based on combination of stem cells and HA
formulations, is included. The final goal was to offer an integral portrait and a deeper comprehension of the
current applications of HA from bench to bedside.},
organization = {This work was supported by the Ministerio de
Economía, Industria y Competitividad (FEDER
funds, project RTC-2016-5451-1) and FIS2017-85954-R
(Agencia Estatal de Investigación, AEI, Spain, cofunded
by Fondo Europeo de Desarrollo Regional,
ERDF, European Union) and by Junta de Andalucía
(Spain) project P12-FQM-2721. Additional support
was provided by grants from ADVANCE (CAT)
with the support of ACCIÓ (Catalonia Trade &
Investment; Generalitat de Catalunya).},
publisher = {AO Research Institute Davos},
keywords = {Cell therapy},
keywords = {Hyaluronic acid},
keywords = {Tissue engineering},
keywords = {Scaffolding},
keywords = {Encapsulation},
keywords = {Stem cell},
title = {Advances of hyaluronic acid in stem cell therapy and tissue engineering, including current clinical trials},
doi = {10.22203/eCM.v037a12},
author = {López Ruiz, Elena and Jiménez, G. and Álvarez Cienfuegos Rodríguez, Luis and Antich Acedo, Cristina and Sabata, R. and Marchal Corrales, Juan Antonio and Gálvez Martín, P.},
}