@misc{10481/59160,
year = {2017},
month = {8},
url = {http://hdl.handle.net/10481/59160},
abstract = {Objective: The effect of drugs other than alcohol on severity of trauma remains unclear. Pooled data
analyses in previous studies that grouped substances with opposite effects on the central nervous system
(CNS) may have masked the influence of substances on injury severity. The aim was to analyze the effect of
stimulant, hallucinogenic and depressant drugs other than alcohol on injury severity in trauma patients.
Methods: The presence of alcohol, stimulant drugs (cocaine, amphetamines and methamphetamines),
depressant drugs (benzodiazepines, opiates, methadone and barbiturates) and hallucinogenic drugs (THC
and PCP) was analyzed in 1187 patients between 16 and 70 years old admitted to a trauma hospital
between November 2012 and June 2015. Injury severity was determined prospectively as the Injury
Severity Score. A multivariate analysis was used to quantify the strength of association between exposure
to substances and trauma severity, using the presence of alcohol as a stratification variable.
Results: Drugs other than alcohol were found in 371 patients (31.3%): 32 (2.7%) stimulants, 186 (15.3%)
depressants, 78 (6.6%) hallucinogenics and 75 (5.6%) polydrug use. The presence of CNS depressant substances
was associated with increased injury severity only in patients also exposed to alcohol, with an
adjusted odds ratio of 4.63 (1.37-15.60) for moderate injuries and 7.83 (2.53-24.21) for severe.
Conclusion: CNS depressant drugs had a strong influence on injury severity in patients who screened
positive for alcohol consumption.},
abstract = {Objetivo: No está claro qué efecto tienen las drogas distintas del alcohol sobre la gravedad de los traumatismos.
 Los análisis incluidos en estudios previos, que agrupan sustancias con efectos opuestos sobre
 el sistema nervioso central (SNC), pueden haber enmascarado la influencia de estas sobre la gravedad. El
 objetivo fue analizar el efecto de las drogas alucinógenas, estimulantes y depresoras del SNC, diferentes
 del alcohol, sobre la gravedad de las lesiones en pacientes ingresados por traumatismos.
 Métodos: Se analizó la presencia de alcohol, drogas estimulantes (cocaína, anfetaminas y metanfetaminas),
 depresoras (benzodiacepinas, opiáceos, metadona y barbitúricos) y alucinógenas (THC y PCP) en
 1187 pacientes de entre 16 y 70 años de edad ingresados por traumatismo de noviembre de 2012 a junio
 de 2015. La gravedad del traumatismo se determinó prospectivamente mediante la Injury Severity Score.
 Se cuantificó la fuerza de la asociación entre la exposición a sustancias y la gravedad del traumatismo
 mediante un análisis multivariante, utilizando la presencia de alcohol como variable de estratificación. Conclusión: Las drogas depresoras del SNC tuvieron una fuerte influencia en la gravedad del traumatismo
 en los pacientes que además presentaban resultados positivos para consumo de alcohol.},
organization = {This work was supported by the Dirección General de Tráfico,
Spain [No. 0100DGT22389] and the Consejería de Salud, Junta de
Andalucía, Spain [No. PI-0691-2013].},
publisher = {Elsevier BV},
keywords = {Alcohols},
keywords = {Benzodiazepines},
keywords = {Psychotropic drugs},
keywords = {Drugs of abuse},
keywords = {Injury Severity Score},
title = {The effect of central nervous system depressant, stimulant and hallucinogenic drugs on injury severity in patients admitted for trauma},
doi = {10.1016/j.gaceta.2017.06.006},
author = {Cordovilla Guardia, Sergio Alejandro and Lardelli Claret, Pablo and Vilar López, Raquel and López Espuela, Fidel and Guerrero López, Francisco and Fernández Mondéjar, Enrique Ángel},
}