@misc{10481/59127,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/59127},
abstract = {Over the last decade, proanthocyanidins (PACs) are attracting attention not only from the
food industry but also from public health organizations due to their health benefits. It is well-known
that grapes are a good source of PACs and for that reason, the industry is also focused on grape
by-products identification and bioactivity evaluation. Grape seeds extract (GSPE) is a rich source
of PACs, mainly composed of monomeric catechin and epicatechin, gallic acid and polymeric and
oligomeric proanthocyanidins. Thus, this review encompasses the state-of-art structure and the
most recent evidence about the impact of GSPE on chronic diseases, with a focus on oxidative
stress, inflammation and metabolic syndrome (MeS)-related disorders such as obesity, diabetes and
cardiovascular risk disease in vivo to offer new perspectives in the field that allow further research.
Despite the controversial results, is undeniable that PACs from grape seeds are highly antioxidants,
thus, the capacity of GSPE to improve oxidative stress might mediate the inflammation process and the
progress of MeS-related pathologies. However, further well-design animal studies with standardized
dosages and GSPE composition are necessary to shed light into the cause-effect relationship in a more
accurate way to later allow a deeper study of the effect of GSPE in humans.},
publisher = {MDPI},
keywords = {Grape seed by-products},
keywords = {Proanthocyanidins},
keywords = {Metabolic syndrome},
keywords = {Chronic diseases},
keywords = {In vivo animal studies},
title = {Grape Seeds Proanthocyanidins: An Overview of In Vivo Bioactivity in Animal Models},
doi = {10.3390/nu11102435},
author = {Rodríguez Pérez, Celia and García Villanova Ruiz, Belén and Guerra Hernández, Eduardo Jesús and Verardo, Vito},
}