@misc{10481/59117,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/59117},
abstract = {Postnatal nutrition is essential for growth and neurodevelopment. We analyzed the
influence of a new enriched-infant formula with bioactive compounds on growth, neurodevelopment,
and visual function (VF) in healthy infants during their first 18 months of life. A total of 170 infants
were randomized in the COGNIS randomized clinical trial (RCT) to receive a standard infant formula
(SF = 85) or a new experimental infant formula supplemented with functional nutrients (EF = 85). As a
control, 50 breastfed infants (BF) were enrolled. Growth patterns were evaluated up to 18 months of
life; neurodevelopment was assessed by general movements at 2, 3, and 4 months; VF was measured by
cortical visual evoked potentials at 3 and 12 months. No differences in growth and neurodevelopment
were found between groups. Regarding VF, SF and EF infants presented prolonged latencies and
lower amplitudes in the P100 wave than BF infants. In the EF group, a higher percentage of infants
presented response at 7 1/2' of arc at 12 months compared to 3 months of age; a similar proportion of BF
and EF infants presented responses at 7 1/2' of arc at 12 months of age. Early nutritional intervention
with bioactive compounds could narrow the gap in growth and neurodevelopment between breastfed
and formula-fed infants.},
organization = {This project has been funded by Ordesa Laboratories, S.L. Contract University of Granada General
Foundation, No. 3349 and SMARTFOODS (CIEN) Contract University of Granada General Foundation, No.
4003, Spanish Ministry of Economy, Industry and Competitiveness; funded in part by HORIZON 2020 EU
DynaHEALTH Project (GA No.633595).},
publisher = {MDPI},
keywords = {Breastfeeding},
keywords = {Infant formula},
keywords = {Bioactive compounds},
keywords = {Visual evoked potentials},
keywords = {Growth},
title = {Cortical Visual Evoked Potentials and Growth in Infants Fed with Bioactive Compounds-Enriched Infant Formula: Results from COGNIS Randomized Clinical Trial},
doi = {10.3390/nu11102456},
author = {Nieto-Ruiz, Ana and García Santos, José Antonio and G. Bermúdez, Mercedes and Herrnan, Florian and Diéguez Castillo, Estefanía and Sepúlveda Valbuena, Natalia and García García, Salomé and Miranda León, María Teresa and Castellar, Roser de and Rodríguez-Palmero, Maria and Catena Martínez, Andrés and Campoy Folgoso, Cristina},
}