@misc{10481/59109,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/59109},
abstract = {Iron deficiency anemia (IDA) is one of the most prevalent nutritional deficiencies worldwide.
Iron plays critical roles in nervous system development and cognition. Despite the known detrimental
consequences of IDA on cognition, available studies do not provide molecular mechanisms elucidating
the role of iron in brain functions during iron deficiency and recovery with dairy components. In
this study, 100 male Wistar rats were placed on a pre-experimental period of 40 days and randomly
divided in two groups: a control group receiving a normal-Fe diet, (45 mg/kg), and an Fe-deficient
group receiving a low-Fe diet (5 mg/kg). At day 40, 10 rats per group were sacrificed to anemia
control, and 80 rats were divided into eight experimental groups fed with fermented goat or cow
milk-based diets, with normal Fe content or Fe overload (450 mg/kg) for 30 days. IDA decreased
most of the parameters related to brain molecular functions, namely dopamine, irisin, MAO-A,
oxytocin,  -endorphin, and alpha-MSH, while it increased synaptophysin. These alterations result in
an impairment of brain molecular functions. In general, during anemia recovery, fermented goat
milk diet consumption increased dopamine, oxytocin, serotonin, synaptophysin, and alpha-MSH, and
decreased MAO-A and MAO-B, suggesting a potential neuroprotective effect in brain functions,
which could enhance brain molecular functions.},
organization = {This study was supported by the Excellence Research Project (P11-AGR-7648) from the Regional
Government of Andalusia},
publisher = {MDPI},
keywords = {Iron deficiency anemia},
keywords = {Fermented goat milk},
keywords = {Brain molecular functions},
keywords = {Neuroprotective effect},
title = {Fermented Goat Milk Consumption Enhances Brain Molecular Functions during Iron Deficiency Anemia Recovery},
doi = {10.3390/nu11102394},
author = {Moreno Fernández, Jorge and López Aliaga, María Inmaculada and García Burgos, María and Muñoz Alférez, María José and Díaz Castro, Javier},
}