@misc{10481/58886,
year = {2018},
month = {1},
url = {http://hdl.handle.net/10481/58886},
abstract = {In the presented study, a new methodology based on the use of deep eutectic solvents
(DESs) and microwave-assisted extraction (MAE) and subsequent analysis by HPLC-DAD-ESITOF-
MS was proposed for the extraction of phenolic compounds from olive leaf. Nine different
DESs, using choline chloride as hydrogen bond acceptor in combination with different hydrogen
bond donors (four polyalcohols, three organic acids, one sugar and urea), were firstly scanned. A
total of 48 phenolic compounds were identified in the olive leaf using HPLC-DAD-ESI-TOF-MS.
Experimental results and multivariate data analysis pointed to choline chloride-ethyleneglycol as
being the most effective within the tested DESs, showing extraction yields similar to those exhibited
by conventional solvents. A Box-Behnken Design and response surface methodology were applied
with the aim to optimize the main parameters involved in the extraction process. The optimal extraction
conditions were 79.6 ºC of temperature, 43.3% of water and 16.7 min of irradiation time. Correlation
coefficients (R2> 0.98) indicated a good relationship between experimental data and the
fitted quadratic term models. Results indicated that DESs could be a sustainable alternative to traditional
solvents for the extraction of bioactive compounds among many other applications.},
organization = {Thanks to the Spanish Ministry of Economy and Competitiveness
(MINECO) (AGL2015-67995-C3-2-R) and the
Andalusian Regional Government Council (P11-CTS-7625).
M.E. Alañón also thanks to Ministry of Education and
Competitiveness for the postdoctoral contract Juan de la
Cierva-Incorporación (IJCI-2014-21664).},
publisher = {Elsevier BV},
keywords = {Deep eutectic solvents},
keywords = {Green chemistry},
keywords = {Olive leaf},
keywords = {Phenolic compounds},
keywords = {Microwave assisted extraction},
title = {Choline chloride derivative-based deep eutectic liquids as novel green alternative solvents for extraction of phenolic compounds from olive leaf},
doi = {10.1016/j.arabjc.2018.01.003},
author = {Alañón, María Elena and Ivanovic, M. and Gómez Caravaca, Ana María and Arráez Román, David and Segura Carretero, Antonio},
}