@misc{10481/58809,
year = {2019},
month = {1},
url = {http://hdl.handle.net/10481/58809},
abstract = {Helicobacter pylori is a human pathogenic bacterium with a high genomic plasticity.
Although the functional CRISPR-Cas system has not been found in its genome,
CRISPR-like loci have been recently identified. In this work, 53 genomes from different
geographical areas are analyzed for the search and analysis of variability of this type of
structure. We confirm the presence of a locus that was previously described in the
VlpC gene in al lgenomes, and we characterize new CRISPR-like loci in other genomic
locations. By studying the variability and gene location of these loci, the evolution and
the possible roles of these sequences are discussed. Additionally, the usefulness of this
type of sequences as a phylogenetic marker has been demonstrated, associating the
different strains by geographical area.},
publisher = {PeerJ},
keywords = {Variability CRISPR-like},
keywords = {VlpC gene},
keywords = {Phylogenetic marker},
keywords = {Helicobacter pylori},
title = {Detection and variability analyses of CRISPR-like loci in the H. pylori genome},
doi = {10.7717/peerj.6221},
author = {García Zea, Jerson Alexander and Herrán Moreno, Roberto De La and Robles Rodríguez, Francisca and Navajas Pérez, Rafael and Ruiz Rejón, Carmelo},
}