@misc{10481/58756,
year = {2019},
month = {11},
url = {http://hdl.handle.net/10481/58756},
abstract = {Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay
treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor
can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated
mainly by tissue inhibitors of metalloproteinases (TIMPs) and histone deacetylases (HDACs), may
also contribute to tumor development by modifying its activity after RT. The aim of this work was to
study the effects of RT on the expression of MMPs, TIMPs and HDACs on different cell subpopulations
in MCF-7, MDA-MB-231 and SK-BR-3 cell lines. We assessed the in vitro expression of these genes in
different 3D culture models and induced tumors in female NSG mice by orthotopic xenotransplants.
Our results showed that gene expression is related to the cell subpopulation studied, the culture
model used and the single radiation dose administered. Moreover, the crucial role played by the
microenvironment in terms of cell interactions and CSC plasticity in tumor growth and RT outcome is
also shown, supporting the use of higher doses (6 Gy) to achieve better control of tumor development},
organization = {This research was funded by the FUNDACIÓN PROGRESO Y SALUD, Consejería de Igualdad, Salud y
Políticas Sociales, Junta de Andalucía (PI-730), the INSTITUTO DE SALUD CARLOS III, Ministerio de Ciencia,
Innovación y Universidades (PIE16-00045) and by the Chair “Doctors Galera-Requena in cancer stem cell research”
(CMC-CTS963).},
publisher = {MDPI},
keywords = {Breast cancer outcomes},
keywords = {Cancer stem cells},
keywords = {Stemness phenotype},
keywords = {Matrix metalloproteases},
keywords = {Targeted treatment},
keywords = {Radiotherapy},
keywords = {Irradiation},
title = {Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment},
doi = {10.3390/cancers11111781},
author = {Olivares Urbano, María Auxiliadora and Griñán Lisón, Carmen and Ríos Arrabal, Sandra and Artacho Cordón, Francisco and Torralbo, Ana Isabel and López Ruiz, Elena and Marchal Corrales, Juan Antonio and Núñez Torres, María Isabel},
}