@misc{10481/58625,
year = {2019},
url = {http://hdl.handle.net/10481/58625},
abstract = {A novel macrocyclic construct consisting of a pyrazolopyrimidine scaffold concatenated to a benzene ring
through two triazoles has been developed to investigate uncharted chemical space with bioactive potential. The 18-atom
macrocycle was assembled via a double copper-catalyzed alkyne−azide cycloaddition (CuAAC) reaction between 1,3-
bis(azidomethyl)benzene and a bis-propargylated pyrazolo[3,4-d]pyrimidine core. The resulting macrocycle was functionalized
further into a multicyclic analog that displays selective inhibitory activity against the receptor tyrosine kinase AXL.},
organization = {O.C.-L. and B.L. thank Spain Ministry of Education, Culture
and Sport and the Erasmus + Traineeship programme for
funding, respectively. C.T. thanks the CMVM for a Principal’s
Scholarship. F.F. acknowledges support from Universidad de
Granada. SHM and AU-B are grateful to Scottish Power and
CRUK for funding.},
publisher = {American Chemical Society},
title = {Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity},
doi = {10.1021/acsomega.9b03525},
author = {Cruz López, Olga María and Franco Montalbán, Francisco},
}