@misc{10481/58608,
year = {2019},
month = {11},
url = {http://hdl.handle.net/10481/58608},
abstract = {The prevalence of renal and cardiovascular disease (CVD) in patients with systemic lupus
erythematosus (SLE) is higher than in general populations. Recently, a causal role of gut microbiota
on the development of immune responses in SLE has been described. Probiotic consumption changes
the composition of gut microbiota, preventing SLE progression. The aim of this review is to explore
the role of the gut microbiota in the development of renal and cardiovascular disease in SLE and
how probiotics could be a therapeutic option. Despite strong evidence on the beneficial effects of
probiotics in the development of autoimmunity and nephritis in SLE, only a few studies described the
protective effects of Lactobacillus in important risk factors for CVD, such as endothelial dysfunction
and hypertension in mice. The preventive effects of probiotics in renal and CVD in humans have not
been established yet.},
organization = {This work was supported by grants from Comisión Interministerial de Ciencia y Tecnología, Ministerio
de Economía y competitividad (MINECO) (SAF2014-55523-R, SAF2017-84894-R) and Junta de Andalucía (Proyecto
de excelencia P12-CTS-2722, and CTS 164), with funds from the European Union, and by the Ministerio de
Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV). I.R.-V. is a predoctoral fellow of MINECO;
N.d.l.V. is a predoctoral fellow of Junta de Andalucía and Fondo Social Europeo “FEDER una manera de hacer
Europa”, and M.T. is a postdoctoral fellow of Instituto de Salud Carlos III (Sara Borrell Program).},
publisher = {MDPI},
keywords = {Immune response},
keywords = {Gut microbiota},
keywords = {Endothelial dysfunction},
keywords = {Hypertension},
keywords = {Nephritis},
title = {Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus},
doi = {10.3390/nu11112676},
author = {de la Visitación, Néstor and Robles-Vera, Iñaki and Toral Jiménez, Marta and Duarte Pérez, Juan Manuel},
}