@misc{10481/58579,
year = {2019},
month = {11},
url = {http://hdl.handle.net/10481/58579},
abstract = {The association between vitamin D [25(OH)D] and bone health has been widely studied in
children. Given that 25(OH)D and bone health are associated with muscular fitness, this could be the
cornerstone to understand this relationship. Hence, the purpose of this work was to examine if the
relation between 25(OH)D and areal bone mineral density (aBMD) was mediated by muscular fitness
in children with overweight/obesity. Eighty-one children (8-11 years, 53 boys) with overweight/obesity
were included. Body composition was measured with dual energy X-ray Absorptiometry (DXA),
25(OH)D was measured in plasma samples and muscular fitness was assessed by handgrip and
standing long jump tests (averaged z-scores were used to represent overall muscular fitness). Simple
mediation analyses controlling for sex, years from peak height velocity, lean mass and season were
carried out. Our results showed that muscular fitness z-score, handgrip strength and standing long
jump acted as mediators in the relationship between 25(OH)D and aBMD outcomes (percentages of
mediation ranged from 49.6% to 68.3%). In conclusion, muscular fitness mediates the association
of 25(OH)D with aBMD in children with overweight/obesity. Therefore, 25(OH)D benefits to bone
health could be dependent on muscular fitness in young ages.},
organization = {This study was supported by the Spanish Ministry of Economy and Competitiveness (Reference
DEP2013-47540). This study takes place thanks to the additional funding from the University of Granada, UGR
Research and Knowledge Transfer Fund (PPIT) 2016, Excellence actions: Units of Scientific Excellence; Scientific
Unit of Excellence on Exercise and Health (UCEES) and the European Regional Development Funds (ERDF, ref.
SOMM17/6107/UGR). In addition, this study was further supported by the SAMID III network, RETICS, funded
by the PN I+D+I 2017-2021 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion and
the European Regional Development Fund (ERDF) (Ref. RD16/0022). L.G-M is supported by a fellowship from
“la Caixa” Foundation (ID 100010434) and the fellowship code is LCF/BQ/PR19/11700007. J.H.M. and J.M.-G. are
supported by the Spanish Ministry of Education, Culture and Sport (FPU15/02645 and FPU14/06837, respectively).},
publisher = {MDPI},
keywords = {Vitamin D},
keywords = {Strength},
keywords = {Bone health},
keywords = {Childhood and youth},
keywords = {Obesity},
title = {Muscular Fitness Mediates the Association between 25-Hydroxyvitamin D and Areal Bone Mineral Density in Children with Overweight/Obesity},
doi = {10.3390/nu11112760},
author = {Gil Cosano, José Juan and Gracia Marco, Luis Andrés and Ubago Guisado, Esther and Migueles Hidalgo, Jairo and Mora González, José Rafael and Escolano Margarit, María Victoria and Gómez Vida, José María and Maldonado Lozano, José and Ortega Porcel, Francisco Bartolomé},
}