@misc{10481/58544,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/58544},
abstract = {Vitamin D deficiency is a worldwide health problem that, in addition to its well-known
negative effects on musculoskeletal health, has been related to a wide range of acute and chronic
age-related diseases. However, little is known about the association of body composition with the
active, hormonal form of vitamin D, 1,25-dihydroxyvitamin D plasma levels (1,25(OH)2D). Therefore,
the aim of this study was to investigate the association of 1,25(OH)2Dwith body composition including
lean and fat body mass as well as bone mineral density (BMD) in middle-aged sedentary adults. Atotal
of 73 (39 women) middle-aged sedentary adults (53.7   5.1 years old) participated in the current study.
We measured weight and height, and we used dual energy X-ray absorptiometry to measure lean body
mass, fat body mass and BMD. Body mass index (BMI), lean mass index (LMI), and fat mass index (FMI)
were calculated. 1,25(OH)2D was measured using a DiaSorin Liaison®immunochemiluminometric
analyzer. The results showed a negative association of 1,25(OH)2D with BMI, LMI and BMD
(  = -0.274, R2 = 0.075, p = 0.019;   = -0.268, R2 = 0.072, p = 0.022; and   = -0.325, R2 = 0.105,
p = 0.005, respectively), which persisted after controlling for age and sex. No significant differences in
1,25(OH)2D across body weight status were observed after controlling for the same covariates. In
summary, our results suggest that 1,25(OH)2D could be negatively associated with BMI, LMI and
BMD whereas no association was found with FMI in middle-aged sedentary adults},
organization = {A.D.-l.-O. is funded by the Spanish Ministry of Education (FPU15/03960). L.G.-M. is supported by
a fellowship from “la Caixa” Foundation (ID 100010434) and the fellowship code is LCF/BQ/PR19/11700007.
F.J.A.-G. is funded by the Spanish Ministry of Education (FPU14/04172), the University of Granada Plan Propio
de Investigación 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)-and Plan Propio de
Investigación 2018-Programa Contratos-Puente.},
publisher = {MDPI},
keywords = {Vitamin D},
keywords = {Calcitriol},
keywords = {Body mass index},
keywords = {Lean mass},
keywords = {Fat mass},
keywords = {Bone mineral density},
title = {Relationship between 1,25-Dihydroxyvitamin D and Body Composition in Middle-Aged Sedentary Adults: The FIT-AGEING Study},
doi = {10.3390/nu11112567},
author = {De la O Puerta, Alejandro and Jurado Fasoli, Lucas and Castillo, Manuel J. and Gracia Marco, Luis Andrés and Gutiérrez Sáinz, Ángel and Amaro Gahete, Francisco José},
}