@misc{10481/58389,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/58389},
abstract = {The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative
microenvironment in adipose tissue. This study was conducted in a subsample (n=144) of the GraMo cohort
(Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were
quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted
for potential confounders.
Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx)
activity [exp(β)=1.20, p=0.060] and decreased levels of reduced glutathione (GSH) [exp(β)=0.55,
p=0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione
reductase (GRd) activity [exp(β)=0.83, exp(β)=0.72, respectively], and BPA was borderline associated
to increased levels of oxidized glutathione (GSSG) [exp(β)=1.73, p-value=0.062]. MeP was inversely
associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of
thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79].
Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the
activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as
a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.},
organization = {This research was supported
in part by research grants from the European Union Commission
(H2020-EJP-HBM4EU and SOE1/P1/F0082), Biomedical Research
Networking Center-CIBER de Epidemiología y Salud Pública
(CIBERESP), from the Institute of Health Carlos III, supported by
European Regional Development Fund/FEDER (FIS-PI13/02406, FISPI14/
00067, FIS-PI16/01820, FIS-PI16/01812, FIS-PI16/01858 and
FIS-PI17/01743), and from the Consejería de Salud, Junta de Andalucía
(PS-0506-2016). Funding for the equipment used was provided by
Velux Fonden, Augustinus Fonden and Svend Andersen Fonden. The
authors thank Kirsten og Freddy Johansens Fond and the International
Centre for Research and Research Training in Endocrine Disruption of
Male Reproduction and Child Health (EDMaRC, Rigshospitalet,
Copenhagen University) for economic support. Dr. Juan Pedro Arrebola
is under contract within Ramón y Cajal Program (Ministerio de
Economía, Industria y Competitividad de España, RYC-2016-20155).},
publisher = {Elsevier BV},
keywords = {Environmental phenols},
keywords = {Oxidative stress},
keywords = {Adipose tissues},
keywords = {Parabens},
title = {Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain},
doi = {10.1016/j.envint.2019.105118},
author = {Artacho Cordón, Francisco and Ríos Arrabal, Sandra and León, J. and Frederiksen, Hanne and Sáenz, J.M. and Martín-Olmedo, Piedad and Fernández M. F. and Olea Serrano, Nicolás and Arrebola Moreno, Juan Pedro},
}