@misc{10481/58220,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/58220},
abstract = {The extracellular matrix (ECM) is a network of di erent proteins and proteoglycans that
controls di erentiation, migration, repair, survival, and development, and it seems that its remodeling
is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation
in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM
components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence
of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a
challenge to treat the metabolic diseases. This review is focused at identifying the putative role of
ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it
is a ected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose
tissue expansion to prevent metabolic diseases.},
publisher = {MDPI},
keywords = {Obesity},
keywords = {Adipose tissues},
keywords = {Extracellular-matrix},
keywords = {Insulin resistance},
title = {Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases},
doi = {10.3390/ijms20194888},
author = {Ruiz Ojeda, Francisco Javier and Méndez Gutiérrez, Andrea and Aguilera García, Concepción María and Plaza Díaz, Julio},
}