@misc{10481/58093,
year = {2018},
month = {8},
url = {http://hdl.handle.net/10481/58093},
abstract = {This study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted
bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were
studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after
maxillary sinus grafting procedures. Musashi-1 was analyzed by immunohistochemistry and RT-PCR.
MSI1 was detected in osteoblasts and osteocytes in 97.4% (38/39) of grafted areas. In native bone,
MSI1 was detected in only 66.6% (12/18) of the biopsies, mainly in osteocytes. Detection of MSI1 was
significantly higher in osteoprogenitor mesenchymal cells of grafted biopsies (p < 0.001) but minor in
smooth muscle and endothelial cells; no expression was detected in adipocytes. The mesenchymal cells
of the non-mineralized tissue of native bone showed very low nuclear expression of MSI1, in comparison
to fusiform cells in grafted areas (0.28(0.13) vs. 2.10(0.14), respectively; p < 0.001). Additionally, the
detection of MSI1 mRNA was significantly higher in biopsies from grafted areas than those from native
bone (1.00(0.51) vs. 60.34(35.2), respectively; p = 0.029). Thus, our results regardig the significantly
higher detection of Musashi-1 in grafted sites than in native bone reflects its importance in the
remodeling/repair events that occur after maxillary sinus floor elevation in humans.},
organization = {This investigation was partially supported by Research Groups #CTS-138
and #CTS-1028 (Junta de Andalucía, Spain). MPM was supported by the Andalucía Talent Hub Program from
the Andalusian Knowledge Agency (co-funded by the European Union’s Seventh Framework Program, Marie
Skłodowska-Curie actions (COFUND – Grant Agreement n° 291780) and the Ministry of Economy, Innovation,
Science and Employment of the Junta de Andalucía).},
publisher = {Springer Nature},
title = {Increased Expression of Musashi-1 Evidences Mesenchymal Repair in Maxillary Sinus Floor Elevation},
doi = {10.1038/s41598-018-29908-3},
author = {O'Valle Ravassa, Francisco Javier and Buitrago, Juan G. de and Hernández Cortés, Pedro Manuel and Padial Molina, Miguel and Crespo-Lora, Vicente and Cobo, Marien and Aguilar Peña, David and Galindo Moreno, Pablo Antonio},
}