@misc{10481/58015,
year = {2018},
month = {11},
url = {http://hdl.handle.net/10481/58015},
abstract = {Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals,
decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative
study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded
gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host
immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage specific
differences in core metabolism and protein families historically targeted for drug development. From an in silico screen,
we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource
provides a much-needed boost for the research community to understand and combat parasitic worms.},
organization = {The work was supported by funding from Wellcome (206194),
Medical Research Council (MR/L001020/1), and Biotechnology and Biological Sciences
Research Council (BB/K020048/1) to M.B., and US National Institutes of Health
(NIH)–National Human Genome Research Institute grant number U54HG003079,
National Institute of Allergy and Infectious Diseases grant number AI081803, and
National Institute of General Medical Sciences grant number GM097435 to M.M.
Genome sequencing and analysis in Edinburgh was supported by EU SICA award
242131 ‘Enhanced Protective Immunity Against Filariasis’ (EPIAF) (to D.W.T.). S.A.
Babayan. was also supported by the EU project EPIAF. G. Koutsovoulos was supported
by a BBSRC/Edinburgh University PhD scholarship and D.R.L. by a joint Edinburgh
University/James Hutton Institute PhD scholarship. J.E.A. was supported by MRC grant
MR/K01207X/1. J.P. and S.S. were supported by the National Institutes of Health/NIAID
(R21 AI126466) and the Natural Sciences and Engineering Research Council of Canada
(RGPIN-2014-06664). Additional computing resources were provided through Compute
Canada by the University of Toronto SciNet HPC Consortium. R.M.M. was supported
by a Wellcome Investigator Award (ref. 106122) and Wellcome core funding to the
Wellcome Centre for Molecular Parasitology (Ref 104111). J.B.M. was supported by the
Scottish Government RESAS. T.S. was supported by the Institute of Parasitology, BC CAS
(RVO: 60077344). A.R.L. and P.M. were supported by a Strategic Award from Wellcome
(WT104104/Z/14/Z) and the Member States of the European Molecular Biology
Laboratory (EMBL). Schistosome samples were obtained from the SCAN repository
(Wellcome grant 104958).},
publisher = {Springer Nature},
title = {Comparative genomics of the major parasitic worms},
doi = {10.1038/s41588-018-0262-1},
author = {Coghlan, Avril and Cruz-Bustos, Teresa and Osuna Carrillo De Albornoz, Antonio and Gómez Samblás, María Mercedes},
}