@misc{10481/57958,
year = {2018},
month = {8},
url = {http://hdl.handle.net/10481/57958},
abstract = {Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in
clinical practice, which can have adverse effects on the osteoblast. The objective of this
study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene
expression of different markers related to osteoblast maturation and function when
treated in vitro with different NSAIDs. Expression of RUNX-2, COL-I, OSX, was reduced by treatment with all studied
NSAIDs, OSC expression was reduced by all NSAIDs except for ketoprofen, naproxen,
or piroxicam. Expression of BMP-7 was reduced by all NSAIDs; BMP-2 was reduced by
all except for naproxen. In general, NSAID treatment increased the expression of TGF-
 1, but not of its receptors (TGF -R1, TGF -R2, and TFG -R3), which was either
unchanged or reduced by the treatment. These data confirm that NSAIDs can affect osteoblast physiology, suggesting
their possible impact on bone.},
organization = {This study was supported by research group BIO277 (Junta de Andalucía) and Department
of Nursing (University of Granada). The work outlined in this article has been supported
by the Spanish Ministry of Education under FPU fellowship reference FPU15-05635 and
FPU16-04141.},
publisher = {PeerJ},
keywords = {Bone tissue},
keywords = {Human osteoblasts},
keywords = {Differentiation},
keywords = {Gene expression},
keywords = {NSAIDs},
title = {Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts},
doi = {10.7717/peerj.5415},
author = {Melguizo Rodríguez, Lucía Raquel and Costela Ruiz, Víctor Javier and Manzano Moreno, Francisco Javier and Illescas Montes, Rebeca and Ramos Torrecillas, Javier and García Martínez, Olga and Ruiz Rodríguez, Concepción},
}