@misc{10481/57944,
year = {2019},
url = {http://hdl.handle.net/10481/57944},
abstract = {We have recently shown that radiotherapy may not only be a successful local and regional treatment
but, when combined with MSCs, may also be a novel systemic cancer therapy. This study aimed to investigate the
role of exosomes derived from irradiated MSCs in the delay of tumor growth and metastasis after treatment with
MSC + radiotherapy (RT). The tumor cell loss rates found after treatment with the combination of MSC and RT and for exclusive RT, were:
44.4% % and 12,1%, respectively. Concomitant and adjuvant use of RT and MSC, increased the mice surviving time 22,5%
in this group, with regard to the group of mice treated with exclusive RT and in a 45,3% respect control group. Moreover,
the number of metastatic foci found in the internal organs of the mice treated with MSC + RT was 60% less than the
mice group treated with RT alone. We reasoned that the exosome secreted by the MSC, could be implicated in tumor
growth delay and metastasis control after treatment. Our results show that exosomes derived form MSCs, combined with radiotherapy, are determinant in
the enhancement of radiation effects observed in the control of metastatic spread of melanoma cells and suggest that
exosome-derived factors could be involved in the bystander, and abscopal effects found after treatment of the tumors
with RT plus MSC. Radiotherapy itself may not be systemic, although it might contribute to a systemic effect when used
in combination with mesenchymal stem cells owing the ability of irradiated MSCs-derived exosomes to increase the
control of tumor growth and metastasis.},
organization = {This work was supported by CNPq, Conselho Nacional de
Desenvolvimento Científico e Tecnológico – Brasil, Junta de Andalucía,
project of Excellence from Junta de Andalucía P12-CTS-383 to FJO, Spanish
Ministry of Economy and Competitiveness SAF2015-70520-R to FJO and
JMRdA, RTICC RD12/0036/0026 and CIBER Cáncer ISCIII CB16/12/00421 to
FJO.},
publisher = {Springer Nature},
keywords = {Experimental radiotherapy},
keywords = {Bystander effect},
keywords = {Abscopal effect},
keywords = {Mesenchymal stem cells},
keywords = {Cell therapy},
keywords = {Metastasis spread},
keywords = {Proteomic analysis},
keywords = {Annexin A1},
keywords = {Melanoma xenograft},
title = {Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci},
doi = {10.1186/s12943-018-0867-0},
author = {Arujo Farias, Virgínea de and O'Valle Ravassa, Francisco Javier and Serrano Saenz, Santiago and Anderson, Per Olof and Andrés, Eduardo and López-Peñalver, Jesús and Tovar Gálvez, María Isabel and Nieto, Ana and Santos, Ana and Martín, Francisco and Expósito, José and Oliver, Javier and Ruiz De Almodóvar Rivera, José Mariano},
}