@misc{10481/57927,
year = {2019},
url = {http://hdl.handle.net/10481/57927},
abstract = {Mendelian randomization is
a method for exploring observational associations to find
evidence of causality. To apply Mendelian randomization between
risk factors/phenotypic traits (exposures) and PD in a
large, unbiased manner, and to create a public resource
for research. We observed evidence for causal associations
between 12 exposures and risk of PD. Of these, nine
were effects related to increasing adiposity and
decreasing risk of PD. The remaining top three exposures
that affected PD risk were tea drinking, time spent
watching television, and forced vital capacity, but these
may have been biased and were less convincing. Other
exposures at nominal statistical significance included
inverse effects of smoking and alcohol. We present a new platform which offers
Mendelian randomization analyses for a total of 5,839
genome-wide association studies versus the largest
PD genome-wide association studies available
(https://pdgenetics.shinyapps.io/MRportal/). Alongside,
we report further evidence to support a causal
role for adiposity on lowering the risk of PD. © 2019
The Authors. Movement Disorders published by Wiley
Periodicals, Inc. on behalf of International Parkinson
and Movement Disorder Society.},
organization = {AJN reports grants from Parkinson’s UK, Barts Charity, Leonard Wolfson Experimental Neurology Centre, UCL
Movement Disorders Centre and the Virginia Kieley Benefaction; honoraria or consultancy fees from Britannia,
Global Kinetics Corporation, Profile Pharmaceuticals, Guide point, Biogen and Roche. KH and DAH are employees
of 23andMe and hold stock or stock options in 23andMe. DAL reports grants from the Medical Research Council,
numerous charitable funders,Medtronic and Roche. ZG-O reports consultancy fees from Inceptions Sciences,Idorsia,
Denali, Lysosomal Therapeutics inc. HM reports reports consultancy from Biogen, UCB, Abbvie, Denali, Biohaven;
lecture fees/honoraria from Biogen, UCB,C4X Discovery, GE-Healthcare, Welcome Trust, Movement Disorders Society;
Research Grants from Parkinson’s UK, Cure Parkinson’s Trust, PSP Association, CBD Solutions, Drake Foundation,
Medical Research Council. Dr Morris is a co-applicanton a patent application related to C9ORF72
(PCT/GB2012/052140).},
publisher = {Wiley},
keywords = {Mendelian randomization},
keywords = {Parkinson´s disease},
keywords = {Public resource},
keywords = {Risk factor},
title = {The Parkinson’s Disease Mendelian Randomization Research Portal},
doi = {10.1002/mds.27873},
author = {Noyce, Alastair and Brandes Ciga, Sara and Durán Ogalla, Raquel},
}