@misc{10481/57863,
year = {2018},
month = {9},
url = {http://hdl.handle.net/10481/57863},
abstract = {Overweight, obesity, and gestational diabetes (GD) during pregnancy may negatively affect
neurodevelopment in the offspring. However, the mechanisms are unclear and objective
measures of neurodevelopment in infancy are scarce. We hypothesized that these maternal
metabolic pathologies impair cortical visual evoked potentials (cVEPs), a proxy for visual
and neuronal maturity. At 3 months of age, visual acuity was significantly poorer in offspring born to GD mothers. At
18 months of age, there were no differences in visual acuity but infants born to GD mothers
had significantly longer latencies of cVEPs when measured at 15', and 30' of arc. The group
differences at 30' remained significant after confounder adjustment (mean [SD] 121.0 [16.0]
vs. 112.6 [7.6] ms in controls, p = 0.007) and the most prolonged latencies were observed in offspring to GD mothers with concurrent overweight (128.9 [26.9] ms, p = 0.002) and obesity
(118.5 [5.1] ms, p = 0.020). Infants born to mothers with GD, particularly those with concurrent overweight or obesity,
have prolonged latencies of visual evoked potentials at 18 months of age, suggesting that
this maternal metabolic profile have a long lasting, non-optimal, effect on infants brain
development.},
organization = {This work was supported by Spanish
Ministry of Innovation and Science. Junta de
AndalucõÂa: Excellence Projects (P06-CTS-02341 [to
CC]); Spanish Ministry of Education (Grant no.
SB2010- 0025 [to CC]); Spanish Ministry of
Economy and Competitiveness (BFU2012-40254-
C03-01 [to CC]); Abbott Laboratories, Granada,
Spain; Henning and Johan Throne-Holst's foundation (Post Doc scholarship [to SKB]).},
publisher = {PLOS},
title = {Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes},
doi = {10.1371/journal.pone.0203754},
author = {Torres Espinola, Francisco Jose and Berglund, Staffan K. and García García, Salomé and Pérez García, Miguel and Catena Martínez, Andrés and Rueda Valdivia, Ricardo and Sáez, Jose Antonio and Campoy Folgoso, Cristina},
}