@misc{10481/57855,
year = {2016},
url = {http://hdl.handle.net/10481/57855},
abstract = {The objective of this study was to determine
whether gynecological and periodontal clinical
parameters and the immunohistochemical expression in
placental chorionic villi of the markers cyclooxygenase-
2 (COX-2), interleukin (IL)-1β, vascular endothelial
growth factor receptor 1 (VEGFR1), podoplanin, and
Heat Shock Protein (HSP70) are associated with preterm
birth (PB) and/or low birth weight (LBW) neonates.
Material and methods: An observational casecontrol
study was performed in 130 puerperal women:
mothers of PB/LBW neonates (cases, n=65) and mothers
of full-term normal-weight neonates (controls, n=65).
Data were gathered from all participants on sociodemographic,
gynecological, and periodontal variables
and on placental immunohistochemical COX-2, IL-1β,
VEGFR1, podoplanin, and HSP70 expression.
Results: Among the 42 women with mild/moderate
periodontitis or gingivitis, the studied periodontal
variables were significantly worse and the placental
COX-2 (p=0.043), HSP70 (p=0.001), IL-1β (p=0.001),
VEGFR1 (p=0.032), and podoplanin (p=0.058)
expressions were significantly higher in the cases than in
the controls. In comparison to the mothers without
periodontitis, only COX-2 (p=0.026) and VEGFR1 (p=0.005) expressions were significantly increased in
those with the disease. Increased COX-2 values were
detected in the women with a history of genitourinary
infection (p=0.036), premature rupture of membrane
(p=0.012), or drug treatment (p=0.050).
Conclusions: The etiology of preterm birth and/or
low birth weight is multifactorial and involves
consumption habits, social-health factors, and infectious
episodes. These adverse pregnancy outcomes were
associated with periodontitis and the increased placental
expression of IL-1β, COX-2, VEGFR1, and HSP70.},
organization = {This investigation was partially supported by
Research Group #CTS-138 and #CTS-583 (Junta de Andalucía, Spain).},
publisher = {Universidad de Murcia},
keywords = {Cyclooxygenase 2},
keywords = {Immunohistochemistry},
keywords = {Placenta},
keywords = {Chronic periodontitis},
keywords = {Gingivitis},
title = {Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers},
author = {Pozo, Elena and Mesa Aguado, Francisco Luis and Ikram, Mohamed H. and Puertas Prieto, Alberto and Torrecillas-Martínez, Laura and Ortega-Oller, Inmaculada and Magán Fernández, Antonio and Rodríguez-Martínez, María Dolores and Padial Molina, Miguel and Sánchez Fernández, Elena and Galindo Moreno, Pablo Antonio and O'Valle Ravassa, Francisco Javier},
}