@misc{10481/57852,
year = {2018},
month = {9},
url = {http://hdl.handle.net/10481/57852},
abstract = {In the etiopathogenesis of autism spectrum disorder (ASD), it has
been suggested that a proinflammatory condition, as well as an alteration in
adhesion molecules in the early stages of neurodevelopment, may play a role in the
pathophysiology of the disorder. This study set out to evaluate the plasma levels of certain
inflammatory cytokines, adhesion molecules, and growth factors in a sample of pediatric
patients with ASD and compare them to the levels in a control group of healthy children. Higher levels of NGF were observed in the ASD group compared with the
levels in the control group (p < 0.05). However, in the analysis of the ASD subgroups,
lower plasma levels of NCAM and higher levels of NGF were found in the group of
ASD children without developmental regression compared to the levels in the group of
typically-developing children. These results suggest differences that could be related to different
pathophysiological mechanisms in ASD. There is not a specific profile for the expression
of relevant plasma cytokines, adhesion molecules or growth factors in children with
ASD compared with that in typically-developing children. However, in the ANMR and
AMR subgroups, some of the adhesion molecules and neuronal growth factors show
differences that may be related to synaptogenesis},
organization = {This study was supported by the FUNDACIÓ AGRUPACIÓ
Àmbit de la Infància, 404 Research Grant INVEST from the
Spanish Society of Pediatrics and Red de Salud Materno Infantil
(RED SAMID).},
publisher = {Frontiers Media},
keywords = {Autism spectrum disorder},
keywords = {Cell adhesion molecules},
keywords = {Children},
keywords = {Cytokines},
keywords = {Neurodevelopmental regression},
title = {Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression},
doi = {10.3389/fped.2018.00264},
author = {Gómez-Fernández, Antonio and de la Torre-Aguilar, María José and Gil-Campos, Mercedes and Flores-Rojas, Katherine and Cruz Rico, María and Martín-Borreguero, Pilar and Pérez Navero, Juan Luis},
}