@misc{10481/57706,
year = {2018},
month = {10},
url = {http://hdl.handle.net/10481/57706},
abstract = {Dyslexia and attention deficit hyperactivity disorder (ADHD) are two complex neuro-behaviorally
disorders that co-occur more often than expected, so that reading disability has been linked
to inattention symptoms. We examined 4 SNPs located on genes previously associated to dyslexia
(KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD
(COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of
having one, both or none of these disorders (dyslexia and ADHD). We used a case-control
approach comparing different groups of samples based on each individual diagnosis. In addition,
we also performed a quantitative trait analysis with psychometric measures on the general
population (N = 3357). The results indicated that the significance values for some markers
change depending on the phenotypic groups compared and/or when considering pair-wise
marker interactions. Furthermore, our quantitative trait study showed significant genetic associations
with specific cognitive processes. These outcomes advocate the importance of establishing
rigorous and homogeneous criteria for the diagnosis of cognitive disorders, as well as
the relevance of considering cognitive endophenotypes.},
organization = {The work of MSM and MC was
supported by CONSOLIDER-Ingenio-
2010_COEDUCA (CSD2008-00048). AMA, LB and
AG-L’s work was supported by the Basque
Department of Industry, Tourism and Trade
(Etortek Program), Innovation Technology
Department of Bizkaia and CIBERehd Network. MC was also supported by grants (PSI2015-67353-R),
and Ayuda Centro de Excelencia Severo Ochoa
SEV-2015-0490 from the MINECO, and by grant
(ERC-2011-ADG-295362) from the European
Research Council. The funders had no role in study
design, data collection and analysis, decision to
publish, or preparation of the manuscript},
publisher = {PLOS},
title = {Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples},
doi = {10.1371/ journal.pone.0206431},
author = {Sánchez Morán, Mirian and Bajo Molina, María Teresa},
}