@misc{10481/57702,
year = {2018},
month = {10},
url = {http://hdl.handle.net/10481/57702},
abstract = {This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes
with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association
between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity
and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of
cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type
2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole
sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on
EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration
was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/
mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our
results provide a controlled comprehensive model that integrates relevant neuropsychological and
physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and
quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be
implemented while monitoring depressive symptoms, BMI and glycaemia control.},
organization = {This project is funded
by Instituto de Salud Carlos III (ISCIII), the Spanish Government Official Agency for funding biomedical research -
with competitive grants for the periods 2014–2016, 2015–2017, 2017–2019 and 2018–2020, through the Fondo
de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund [grants:
PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728 PI13/01090
PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522,
PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,
PI17/01441, PI17/00508, PI17/01732, PI17/00926] and the European Research Council [Advanced Research
Grant 2014–2019; agreement #340918]. Additional grants: Acciones Especiales from ISCIIII, Consejería-Salud,
Junta -Andalucía [PI0458/2013, PS0358/2016], Recercaixa-grant 2013 [2013ACUP00194], a SEMERGEN grant,
International Nut & Dried Fruit Council – FESNAD No. 201302. Fundación Patrimonio Comunal Olivarero is
providing the necessary amounts of olive oil. Nuts were initially and only partially provided by Pistachios Growers
and Almond Board of California, for the pilot study. This research was also partially funded by EU-H2020 Grant
(Eat2beNICE/H2020-SFS-2016–2; Ref 728018), PI14/00290 y PI17/1167(Co-funded by European Regional
Development Fund, ERDF, a way to build Europe), PERIS (Generalitat de Catalunya, SLT006/17/00077), Grant
PROMETEO/2017/017 (Generalitat Valenciana) and Grant FEA/SEA 2017 for Primary Care Research. We thank
CERCA Programme/Generalitat de Catalunya for institutional support. ML-M is supported by a predoctoral Grant
of the Ministerio de Educación, Cultura y Deporte (FPU15/02911).},
publisher = {Springer Nature},
title = {Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study},
doi = {10.1038/s41598-018-33843-8},
author = {Mallorqui Bague, Núria and Bueno Cavanillas, Aurora},
}