@misc{10481/57527,
year = {2019},
month = {5},
url = {http://hdl.handle.net/10481/57527},
abstract = {Probiotics, included in functional foods, nutritional supplements, or nutraceuticals, exhibit
different beneficial effects on gut function. They are extensively used to improve the digestive
processes as well as reduce the symptoms and progression of different diseases. Probiotics have
shown to improve dysbiosis and modulate the immune response of the host by interacting with
different cell types. Probiotics and the host can interact in a direct way, but it is becoming apparent
that communication occurs also through extracellular vesicles (EVs) derived from probiotics. EVs are
key for bacteria–bacteria and bacteria–host interactions, since they carry a wide variety of components
that can modulate different signaling pathways, including those involved in the immune response.
Interestingly, EVs are recently starting to be considered as an alternative to probiotics in those cases
for which the use of live bacteria could be dangerous, such as immunocompromised individuals or
situations where the intestinal barrier is impaired. EVs can spread through the mucus layer and
interact with the host, avoiding the risk of sepsis. This review summarizes the existing knowledge
about EVs from different probiotic strains, their properties, and their potential use for the prevention
or treatment of different gastrointestinal diseases.},
organization = {This work was supported by Junta de Andalucia (Spain) (research grants CTS 164 and PI-0206-2016) and
the Spanish Ministry of Economy and Competitiveness (research grant AGL2015-67995-C3-3-R) and cofinanced
by the Fondo Europeo de Desarollo Regional (FEDER) from the European Union. JA-MT is a Ph.D. student
from the Postgraduate Program Nutricion y Ciencias de los Alimentos at the University of Granada (Spain). The
CIBER-EHD is funded by the Instituto de Salud Carlos III.},
publisher = {MDPI},
keywords = {Extracellular vesicles},
keywords = {Gastrointestinal diseases},
keywords = {Tight junctions},
keywords = {TLR signaling},
keywords = {Probiotics},
title = {The Immunomodulatory Properties of Extracellular Vesicles Derived from Probiotics: A Novel Approach for the Management of Gastrointestinal Diseases},
doi = {10.3390/nu11051038},
author = {Molina Tijeras, José Alberto and Gálvez Peralta, Julio Juan and Rodríguez Cabezas, María Elena},
}