@misc{10481/57483,
year = {2019},
month = {9},
url = {http://hdl.handle.net/10481/57483},
abstract = {The objective of this study was to determine the acute (one single dose), subacute (14 days),
and sub-chronic (90 days) toxicity of an aqueous virgin olive oil (VOO) extract rich in hydroxytyrosol
in rats. For acute/subacute toxicity, rats were divided into three groups. The control group received
distilled water (n = 9), another experimental group received a single dose of 300 mg/kg (n = 3), and a
third group received one dose of 2000 mg/kg (n = 4) during 14 days. The sub-chronic study included
60rats distributed in three groups (n = 20: 10 males and 10 females) receiving daily different three
doses of the VOO extract in the drinking water during 90 days: (1) 100 mg/kg, (2) 300 mg/kg, and
(3) 1000 mg/kg. In parallel, a fourth additional group (n = 20: 10 males and 10 females) did not
receive any extract (control group). Clinical signs, body weight, functional observations of sensory
and motor reactivity, hematological and biochemical analyses, and macroscopic and microscopic
histopathology were evaluated. No adverse effects were observed after the administration of the
different doses of the hydroxytyrosol-rich VOO extract, which suggests that the enrichment of VOO
in its phenolic compound is safe, and can be used as functional foods for the treatment of chronic
degenerative diseases.},
organization = {The grant #3650 managed by Fundación General Empresa-Universidad de Granada and the investigation
group CTS-454 “Impacto fisiológico del estrés oxidativo, deporte, actividad física y salud” supported this study},
publisher = {MDPI},
keywords = {Virgin olive oil},
keywords = {Hydroxytyrosol},
keywords = {Acute toxicity},
keywords = {Subacute toxicity},
keywords = {Subchronic toxicity},
title = {Acute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extract},
doi = {10.3390/nu11092133},
author = {Rodríguez Lara, Avilene and Mesa García, María Dolores and Aragón Vela, Jerónimo and Casuso, Rafael A. and Casals Vázquez, Cristina and Zúñiga, Jesús M. and Rodríguez Huertas, Jesús Francisco},
}