@misc{10481/57476,
year = {2019},
month = {9},
url = {http://hdl.handle.net/10481/57476},
abstract = {Coenzyme Q (CoQ) is an essential endogenously synthesized molecule that links different
metabolic pathways to mitochondrial energy production thanks to its location in the mitochondrial
inner membrane and its redox capacity, which also provide it with the capability to work as an
antioxidant. Although defects in CoQ biosynthesis in human and mouse models cause CoQ deficiency
syndrome, some animals models with particular defects in the CoQ biosynthetic pathway have shown
an increase in life span, a fact that has been attributed to the concept of mitohormesis. Paradoxically,
CoQ levels decline in some tissues in human and rodents during aging and coenzyme Q10 (CoQ10)
supplementation has shown benefits as an anti-aging agent, especially under certain conditions
associated with increased oxidative stress. Also, CoQ10 has shown therapeutic benefits in aging-related
disorders, particularly in cardiovascular and metabolic diseases. Thus, we discuss the paradox of
health benefits due to a defect in the CoQ biosynthetic pathway or exogenous supplementation
of CoQ10.},
organization = {This work was supported by grants from Ministerio de Ciencia, Innovación y Universidades, Spain,
and the ERDF (Grant Number RTI2018-093503-B-I00), from the Muscular Dystrophy Association (grant number
602322) and from the University of Granada (grant reference “UNETE”, UCE-PP2017-06). E.B.-C. is supported by
the Junta de Andalucía. P.G.-G. is a “FPU fellow” from the Ministerio de Educación Cultura y Deporte, Spain},
publisher = {MDPI},
keywords = {Mitohormesis},
keywords = {Antioxidants},
keywords = {Aging-related diseases},
keywords = {Mitochondria},
title = {The Paradox of Coenzyme Q10 in Aging},
doi = {10.3390/nu11092221},
author = {Díaz-Casado, Elena and Quiles Morales, José Luis and Barriocanal Casado, Eliana and Battino, Maurizio and López, Luis and Varela López, Alfonso},
}