@misc{10481/57475,
year = {2019},
month = {9},
url = {http://hdl.handle.net/10481/57475},
abstract = {This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and
their association with infant growth and cognition to raise awareness about the programming effect
of maternal health and to promote a healthy prenatal weight. Mother–child pairs (n = 78) were
grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5–24.99),
overweight (BMI = 25–29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined.
Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature
milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than
colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3
ratio and decreased a-linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age
at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs
and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was
positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and
negatively a ected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI
can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy
weight in future generations.},
organization = {This research was funded by the European Commission (DynaHEALTH-HORIZON 2020GANo: 633595)
and the Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-02). Further support was obtained
from, Spanish Ministry of Innovation and Science (Junta de Andalucía), Excellence Projects (P06-CTS-02341).
ADLGP thanks the Mexican government and the National Council on Science and Technology (CONACYT) for
her PhD grant. The funders had no role in the study design, data collection, data analysis, decision to publish, or
preparation of the manuscript.},
publisher = {MDPI},
keywords = {Maternal obesity},
keywords = {Breastfeeding},
keywords = {Fatty acids},
keywords = {Early life nutrition},
keywords = {Colostrum},
title = {The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up},
doi = {10.3390/nu11092154},
author = {de la Garza Puentes, Andrea and Torres Espinola, Francisco Jose and García Valdes, Luz and Escudero Marín, Mireia and Segura López, María Teresa and Campoy Folgoso, Cristina},
}