@misc{10481/57471,
year = {2019},
month = {9},
url = {http://hdl.handle.net/10481/57471},
abstract = {Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common
sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and
cardiovascular diseases. Although strongly recommended for this condition, there are no studies on
the e ectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition,
exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled
trial with a two-arm parallel design aimed at determining the e ects of an interdisciplinary tailored
weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged
18–65 with a body mass index of  25 kg/m2 and severe to moderate OSA randomly assigned to
usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle
intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point,
and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other
neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning
and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of
life, and cost-e ectiveness. INTERAPNEA may serve to establish a cost-e ective treatment not only
for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission
of this condition.},
organization = {This research is supported by the Spanish Ministry of Education and Vocational Training, grant/award
numbers FPU16/01093 and FPU14/04172. The study is also partially supported by the Sleep Research Cathedra
University of Granada-LoMonaco S.L.; the University of Granada Plan Propio de Investigación 2016 -Excellence
actions: Unit of Excellence on Exercise and Health (UCEES); and the Junta de Andalucía, Consejería de
Conocimiento, Investigación y Universidades (European Regional Development Funds, ref. SOMM17/6107/UGR).},
publisher = {MDPI},
keywords = {Obstructive sleep apnoea},
keywords = {Apnoea-hypopnoea index},
keywords = {Obesity},
keywords = {Weight loss},
keywords = {Interdisciplinary lifestyle intervention},
keywords = {Nutrition},
keywords = {Sleep hygiene},
title = {InterdisciplinaryWeight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study},
doi = {10.3390/nu11092227},
author = {Carneiro Barrera, Almudena and Amaro Gahete, Francisco José and Díaz Román, Amparo and Guillén Riquelme, Alejandro and Jurado Fasoli, Lucas and Sáez Roca, Germán and Martín Carrasco, Carlos and Ruiz Ruiz, Jonatan and Buela Casal, Gualberto},
}