@misc{10481/57469,
year = {2019},
url = {http://hdl.handle.net/10481/57469},
abstract = {Prepregnancy maternal obesity is a global health problem and has been associated with offspring
metabolic and mental ill-health. However, there is a knowledge gap in understanding potential neurobiological factors
related to these associations. This study explored the relation between maternal prepregnancy body mass index (BMI) and
offspring brain white matter microstructure at the age of 6, 10, and 26 years in three independent cohorts. Maternal BMI was associated with higher FA and lower MD in multiple brain tracts in offspring aged 10 and
26 years, but not at 6 years of age. Future studies should examine whether our observations can be replicated and explore the
potential causal nature of the findings.},
organization = {This work was supported by the European
Union’s Horizon 2020 research and innovation program [grant
agreement no. 633595 DynaHEALTH] and no. 733206 LifeCycle], the
Netherlands Organization for Health Research and Development
[ZONMW Vici project 016.VICI.170.200]. The PREOBE cohort was
funded by Spanish Ministry of Innovation and Science. Junta de
Andalucía: Excellence Projects (P06-CTS-02341) and Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-01).
The first phase of the Generation R Study is made possible by financial
support from the Erasmus Medical Centre, the Erasmus University,
and the Netherlands Organization for Health Research and Development (ZonMW, grant ZonMW Geestkracht 10.000.1003). The
Northern Finland Birth Cohort 1986 is funded by University of Oulu,
University Hospital of Oulu, Academy of Finland (EGEA), Sigrid
Juselius Foundation, European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643), NIH/NIMH
(5R01MH63706:02)},
publisher = {Springer Nature},
title = {Maternal prepregnancy body mass index and offspring white matter microstructure: results from three birth cohorts},
doi = {10.1038/s41366-018-0268-x},
author = {Verdejo Román, Juan and Torres Espinola, Francisco Jose and Campos, Daniel and Campoy Folgoso, Cristina},
}