@misc{10481/56695,
year = {2019},
url = {http://hdl.handle.net/10481/56695},
abstract = {Data on the radiobiological effects of thermal neutrons are usually obtained from irradiations in a mixed field of neutrons of different energies and gamma rays or from conversion of proton data with similar energies to those created in the neutron capture on nitrogen. Experimental data from irradiations in a pure thermal or cold neutron beam can help to find new values for neutron relative biological effectiveness (RBE) factors, which are useful for BNCT (Boron Neutron Capture Therapy) and radiation protection applications. We present a new experimental setup for radiobiological studies at a cold neutron beam at Institut Laue-Langevin, a beam without fast neutron component and almost no gamma ray contribution. After the irradiation, survival assays are performed to obtain the survival curves. Finally, comparing with a reference photon irradiation, the thermal neutron RBE factors can be calculated. The methodology is outlined at the example of A375 melanoma cells for which new radiobiological data were obtained.},
organization = {Institut Laue-Langevin, Avenue des Martyrs, 38042 Grenoble, France.
Departamento de Física Atómica Molecular y Nuclear, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Departamento de Bioquímica y Biología Molecular III e Inmunología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.},
organization = {We acknowledge financial support for this work from the Fundación Científica de la Asociación Española  Contra  el  Cáncer  (AECC)  under  grant  PS16163811PORR,  Junta  de  Andalucía (Andalusian  Regional  Government),  under  contract  P11-FQM-8229,  Spanish  MINECO  and FEDER  funds  under  contract  FIS2015-69941-C2-1-P,  and  the  founders  of  the  University  of Granada  Chair  Neutrons  for  Medicine:  Spanish  Fundación  ACS  and  Capitán  Antonio. M.P. acknowledges  a  grant  under  the  program  Becas  de  Iniciación  a  la  Investigación  from  the Universidad de Granada (Plan Propio de Investigación).},
keywords = {Neutron radiobiology},
keywords = {Neutron sources},
keywords = {Boron neutron capture therapy},
title = {Neutron radiobiology studies with a pure cold neutron beam: application to the measurement of the thermal neutron RBE of A375 melanoma cells for Boron Neutron Capture Therapy},
author = {Pedrosa-Rivera, María and Ruiz-Magaña, María José and Porras Sánchez, José Ignacio and Praena Rodríguez, Antonio Javier and Torres Sánchez, Pablo and Sabariego Quintanilla, Manuel and Köster, U. and Forsyth, T. and Soldner, T. and Haertlein, M. and Ruiz Ruiz, María Carmen},
}