@misc{10481/56632,
year = {2018},
url = {http://hdl.handle.net/10481/56632},
abstract = {Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such
as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent
evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are
sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study
aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health
outcomes among overweight/obese adolescents from Bogotá, Colombia.
Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11–17 years) attending two
public schools in Bogotá, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be
randomly assigned to an intervention group following one of four curricula: (1) the standard physical education
curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical
education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities,
such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with
an energy expenditure goal of 300 to 500 kcal/session at 75–85% maximum heart rate (HRmax); (3) a low-to-moderate
intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive
activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy
expenditure goal of 300 kcal/session at 55–75% HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25).
The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum.
The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1
week after the end of the intervention program.
Discussion: The translational focus may be suitable for collecting new information in a school setting on the
possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles
and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of
school physical education resources.},
organization = {The HEPAFIT study was carried out with the financial support of Instituto
Colombiano para el Desarrollo de la Ciencia y la Tecnología “Francisco José
de Caldas” COLCIENCIAS (code 59700 and no 122277757900). Katherine
González-Ruíz receive a scholarship from Universidad del Rosario, Colombia,
Escuela de Medicina y Ciencias de la Salud, to do a Doctorate. This article
presents independent research commissioned by COLCIENCIAS under its
Program Grants for Applied Research funding scheme (Convocatoria 777–2017).},
publisher = {Biomed Central},
keywords = {Exercise},
keywords = {Risk factor},
keywords = {Fatty liver},
keywords = {Metabolic syndrome},
keywords = {Overweight},
keywords = {Obesity},
title = {Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): study protocol for a randomized controlled trial},
doi = {10.1186/s13063-018-2721-5},
author = {González-Ruiz, Katherine and Correa-Bautista, Jorge Enrique and Izquierdo, Mikel and García-Hermoso, Antonio and Domínguez-Sánchez, María Andrea and Bustos-Cruz, Rosa Helena and Cañete García-Prieto, Jorge and Martínez-Vizcaíno, Vicente and Lobelo, Felipe and González Jiménez, Emilio and Prieto-Benavides, Daniel Humberto and Tordecilla-Sanders, Alejandra and Schmidt Río Valle, Jacqueline and Pérez, Guillermo and Ramírez-Vélez, Robinson},
}