@misc{10481/55765,
year = {2019},
month = {3},
url = {http://hdl.handle.net/10481/55765},
abstract = {Although dietary iron is a determinant of iron status in animals, body fat mass has
been reported to have an inverse association with iron status in human studies. The goal of
this study was to determine the relationship between Fe homeostasis, body composition, energy
expenditure and neuroendocrine regulators for severe Fe-deficiency anaemia. Forty male Wistar
albino rats recently weaned were divided at random into two groups: the control group was fed
the basal diet, AIN-93G diet (normal-Fe) and the anaemic group received a low-Fe diet for 40 days.
Neuroendocrine parameters that regulate basal metabolism and appetite (thyroid hormones, ghrelin,
glucose-dependent insulinotropic polypeptide (GIP), glucagon, insulin, adrenocorticotropic hormone
and corticosterone), body composition, respiratory volumes, energy expenditure, haematological
and biochemical were assessed. Total body fat was lower, whereas lean mass, free and total water
were higher in the anemic group. O2 consumption, CO2 production, energy expenditure (EE) and
respiratory quotient (RQ) were lower in the Fe-deficient animals. Triiodothyronine and thyroxine
hormones decreased, while thyroid-stimulating hormone increased in the anemic group. Circulating
levels of ghrelin were lower in the anemic group, while GIP, glucagon, insulin, corticosterone and
adrenocorticotropic hormone levels were higher. Fe-deficiency impairs weight gain in the rats,
with marked reductions in lean mass and body fat, indicating lower energy stores.},
organization = {This study was supported by the Excellence Project (P11-AGR-7648) from the Regional Government
of Andalusia.},
publisher = {MDPI},
keywords = {Ferropenic anaemia},
keywords = {Endocrine regulators},
keywords = {Body composition},
keywords = {Energy expenditure},
title = {Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats},
author = {Moreno Fernández, Jorge and Díaz Castro, Javier and Muñoz Alférez, María José and López Aliaga, María Inmaculada},
}