@misc{10481/55760,
year = {2019},
month = {3},
url = {http://hdl.handle.net/10481/55760},
abstract = {Obesity is a global pandemic complex to treat due to its multifactorial pathogenesis—an
unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are
involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly
related to changes in both the function and composition of gut microbiota, which exert an essential role
in modulating energy metabolism. Modifications of gut microbiota composition have been associated
with variations in body weight and body mass index. Lifestyle modifications remain as primary
therapy for obesity and related metabolic disorders. New therapeutic strategies to treat/prevent
obesity have been proposed, based on pre- and/or probiotic modulation of gut microbiota to mimic
that found in healthy non-obese subjects. Based on human and animal studies, this review aimed
to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and
related metabolic complications. Evidence from animal studies and human clinical trials suggesting
potential beneficial effects of prebiotic and various probiotic strains on those physical, biochemical,
and metabolic parameters related to obesity is presented. As a conclusion, a deeper knowledge
about pre-/probiotic mechanisms of action, in combination with adequately powered, randomized
controlled follow-up studies, will facilitate the clinical application and development of personalized
healthcare strategies.},
organization = {Supported by funds from European Union 7th FP KBBE.2013.2.2-02—MyNewGut Project (“Factors
influencing the human gut microbiome and its effect on the development of diet-related diseases and brain
development”, Grant Agreement 613979) and from Spanish Ministry of Economy and Competitiveness GD-Brain
Projects (SAF2015-69265-c2.2).},
publisher = {MDPI},
keywords = {Obesity},
keywords = {Gut microbiota},
keywords = {Probiotics},
keywords = {Prebiotics},
keywords = {Nutrition},
title = {The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity},
doi = {10.3390/nu11030635},
author = {Cerdó, Tomás and García Santos, José Antonio and G. Bermúdez, Mercedes and Campoy Folgoso, Cristina},
}