@misc{10481/55687,
year = {2019},
month = {3},
url = {http://hdl.handle.net/10481/55687},
abstract = {Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA)
and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes
may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of
this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs
of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly
allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the
latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF;
n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age.
FADS minor allele carriership in formula fed infants, especially those supplemented, was associated
with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected,
possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and
DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute
to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.},
organization = {This research was funded by ORDESA Laboratories, S.L., Spanish Ministry of Economy, Industry and
Competitiveness, NEOBEFOOD Project (2010–2013) and SMARTFOODS Project (2014–2018)—CIEN Strategy
(Ministry of Innovation and Science-CDTI) through 2 different contracts established between Ordesa Laboratories
and the University of Granada General Foundation (ref. nº3349 and nº4003, respectively) and between Ordesa
Laboratories and the Bosch Gimpera Foundation/University of Barcelona (ref. n  306811 and 308516). The project
was partially funded by EU Project DynaHEALTH (HORIZON 2020-GA No.633595).},
publisher = {MDPI},
keywords = {Fatty acids},
keywords = {Omega 6},
keywords = {Omega 3},
keywords = {Breast milk},
keywords = {Infant formula},
keywords = {Fatty acid desaturases},
keywords = {Early life nutrition},
keywords = {Control formula},
keywords = {Intervention formula},
keywords = {Exclusive breastfeeding},
title = {The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study},
doi = {10.3390/nu11030602},
author = {Salas Lorenzo, Isabel and Chisaguano Tonato, Aida M. and de la Garza Puentes, Andrea and Espejo Nieto, Ana and Herrmann, Florian and Diéguez Castillo, Estefanía and Castellote, Ana I. and López-Sabater, María del Carmen and Rodríguez-Palmero, Maria and Campoy Folgoso, Cristina},
}