@misc{10481/55419,
year = {2018},
month = {10},
url = {http://hdl.handle.net/10481/55419},
abstract = {This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary
outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in
women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with
SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised
12 weeks of aerobic exercise (2 sessions X 75 min/week) between 40–75% of the individual’s heart
rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity
(PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha
[TFN- α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were
obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no
between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI
-0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison
to the control group, the exercise group significantly increased cardiorespiratory fitness (median
difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of
progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial
stiffness, inflammation, or oxidative stress in women with SLE.},
organization = {This work was supported by Fundación para la Investigación Biosanitaria de Andalucía Oriental (grant
number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017).
BG-C was supported by the Spanish Ministry of Education (FPU15/00002).},
publisher = {MDPI},
keywords = {Exercise},
keywords = {Physical fitness},
keywords = {Aerobic fitness},
keywords = {Physical function},
keywords = {Pulse wave velocity},
keywords = {Autoimmune diseases},
keywords = {Vascular health},
keywords = {Atherosclerosis},
keywords = {Lupus},
keywords = {Inflammatory disease},
title = {Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial},
author = {Soriano‑Maldonado, Alberto and Morillas de Laguno, Pablo and Mario Sabio, José and Gavilán-Carrera, Blanca and Rosales-Castillo, Antonio and Montalbán-Méndez, Cristina and Sáez Urán, Luis Manuel and Callejas Rubio, José Luis and Vargas-Hitos, José Antonio},
}