@misc{10481/55392,
year = {2018},
month = {12},
url = {http://hdl.handle.net/10481/55392},
abstract = {The spectrum and efficacy of available antileishmanial drugs is limited. In the present
work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate
polyamines compounds against three Leishmania species (L. braziliensis, L. donovani and L. infantum)
and the possible mechanism of action. We identified six compounds (3, 5, 6, 7, 8 and 10) effective
against all three Leishmania spp both on extracellular and intracellular forms. These six most active
leishmanicidal compounds also prevent the infection of host cells. Nevertheless, only compound 7 is
targeted against the Leishmania SOD. Meanwhile, on the glucose metabolism the tested compounds
have a species-specific effect on Leishmania spp.: L. braziliensis was affected mainly by 10 and 8,
L. donovani by 7, and L. infantum by 5 and 3. Finally, the cellular ultrastructure was mainly damaged
by 11 in the three Leishmania spp. studied. These identified antileishmania candidates constitute a
good alternative treatment and will be further studied.},
organization = {This research was funded by THE SPANISH MINISTRY OF ECONOMY AND COMPETITIVENESS
(MINECO), CONSOLIDER-INGENIO 2010, grant number CDS2010-00065; THE EUROPEAN RESEARCH
FOUNDATION, grant number ERC-2009-StG-239910; THE MICINN, grant number CTQ2009-08464; and
INNPLANTA, grant number INP-2011-0059-PCT-420000-ACT1.},
publisher = {MDPI},
keywords = {Amastigote},
keywords = {Antileishmania},
keywords = {Antiproliferative},
keywords = {Leishmania spp.},
keywords = {Promastigote},
keywords = {SOD},
keywords = {Tetradentate polyaminic compounds},
keywords = {Ultrastructure},
title = {Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites},
author = {Urbanová, Kristína and Ramírez Macías, Inmaculada and Martín-Escolano, Rubén and Rosales Lombardo, María José and Cussó, Olaf and Serrano, Joan and Llamas Company, Inmaculada and Sánchez Moreno, Manuel and Costas, Miquel and Ribas, Xavi and Marín Sánchez, Clotilde},
}