@misc{10481/54900,
year = {2018},
month = {4},
url = {http://hdl.handle.net/10481/54900},
abstract = {Background: we have evaluated the antihypertensive effect of several flavonoid extracts
in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric
oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or
L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or
purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a
marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit +
Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin
and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic
vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts,
hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these
treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this
study, specially apigenin, may be used as functional food ingredients with potential therapeutic
benefit in arterial hypertension.},
organization = {This report was supported by a grant from the National Spanish R&D Program CENIT of
the Spanish Ministry of Science and Technology denominated “Industrial research diets and food with specific
features for the elderly”, CEN-20091006; Acronym: SENIFOOD.We have not received funds for covering the costs
to publish in open access. We acknowledge the assistance of Justin Davis with the English language.},
publisher = {MDPI},
keywords = {Flavonoids},
keywords = {Nitric oxide},
keywords = {Neart},
keywords = {Kidney},
keywords = {Sodium balance},
keywords = {Phenylephrine},
keywords = {Acetylcholine},
title = {Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats},
author = {Paredes, M. Dolores and Romecín, Paola and Atucha, Noemí M. and O'Valle Ravassa, Francisco Javier and Castillo, Julián and Ortiz, María Clara and García-Estañ, Joaquín},
}