@misc{10481/54124,
year = {2017},
month = {8},
url = {http://hdl.handle.net/10481/54124},
abstract = {We have taken a vital step towards understanding why probiotic bacteria increase iron absorption in the gastrointestinal tract. We show here that Lactobacillus fermentum, one of the main probiotics of the microbiota, exhibits an extraordinary ferric-reducing activity. This activity is predominantly due to an excreted molecule: p-hydroxyphenyllactic acid (HPLA). Reduction of Fe(III) to Fe(II) is essential for iron absorption in the gastrointestinal tract. By reducing Fe(III), HPLA boosts Fe(II) absorption through the DMT1 channels of enterocytes. An in vitro experiment tested and confirmed this hypothesis. This discovery opens new avenues for the treatment of iron deficiency in humans, one of the most common and widespread nutritional disorders in the world.},
keywords = {Iron metabolims},
keywords = {Probiotic bacteria},
keywords = {Lactobacillus fermentum},
keywords = {Iron supplement},
title = {Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption},
doi = {https://doi.org/10.1016/j.foodchem.2017.02.008},
author = {González, Ana and Gálvez Rodríguez, Natividad and Martín, Jesús and Reyes, Fernando and Pérez-Victoria, Ignacio and Domínguez-Vera, Jose M.},
}