@misc{10481/52221,
year = {2017},
month = {11},
url = {http://hdl.handle.net/10481/52221},
abstract = {Enzymes are flexible catalysts, and there has been substantial
discussion about the extent to which this flexibility contributes
to their catalytic efficiency. What has been significantly less
discussed is the extent to which this flexibility contributes to
their evolvability. Despite this, recent years have seen an
increasing number of both experimental and computational
studies that demonstrate that cooperativity and flexibility play
significant roles in enzyme innovation. This review covers key
developments in the field that emphasize the importance of
enzyme dynamics not just to the evolution of new enzyme
function(s), but also as a property that can be harnessed in the
design of new artificial enzymes.},
organization = {The European Research Council has provided financial support under the
European Community’s Seventh Framework Program (FP7/2007-2013)/ERC
Grant Agreement No. 306474. This work was also funded by the Feder
Funds, Grants from the Spanish Ministry of Economy and Competitiveness
(BIO2015-66426-R and CSD2009-00088) and the Human Frontier Science
Program (RGP0041/2017). A.P. is a Wenner-Gren Foundations Postdoctoral
Fellow and S. C. L. K. is a Wallenberg Academy Fellow.},
publisher = {Elsevier B. V.},
title = {Cooperativity and flexibility in enzyme evolution},
doi = {10.1016/j.sbi.2017.10.020},
author = {Pabis, Anna and Risso, Valeria Alejandra and Sánchez Ruiz, José Manuel and Kamerlin, Shina CL},
}