@misc{10481/51253,
year = {2018},
month = {3},
url = {http://hdl.handle.net/10481/51253},
abstract = {Background: Reproductive factors are well known risk factors for breast cancer; however, little is known about how
genetic variants in hormonal pathways interact with that relationship.
Methods: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched
controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and
Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic.
Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the
selected genetic variants and reproductive factors was tested with logistic regression.
Results: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1–2 and > 2 deliveries
were 0.48 (0.28–0.81) and 0.34 (0.19–0.59), and in C carriers they were 0.92 (0.42–1.98) and 0.71 (0.31–1.61). Similar
results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in
rs6018027 had the delivery number effect more pronounced.
Conclusions: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C
allele in rs2229712 did not benefit from this protective effect.},
organization = {This work was partially funded by the “Accion Transversal del Cancer”,
approved by the Spanish Ministry Council on the 11th October 2007; The
Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/
00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva,
PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810,
PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150,
PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación
Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome
Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio
de Economía y Competitividad (MINECO) through the Instituto de Salud
Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del
ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10–2]; The
Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria
de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa
[2010ACUP 00310]; The Regional Government of the Basque Country; The
Consejería de Sanidad de la Región de Murcia; The European Commission
[grants FOOD-CT-2006-036224-HIWATE]; The Spanish Association Against
Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant
2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University
of Oviedo.},
publisher = {BioMed Central},
keywords = {Breast cancer},
keywords = {Genetic interactions},
keywords = {Reproductive factors},
title = {Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project},
doi = {10.1186/s12885-018-4182-3},
author = {Dierssen-Sotos, Trinidad and Palazuelos-Calderón, Camilo and Jiménez Moleón, José Juan and Aragonés, Nuria and Altzibar, Jone M. and Castaño-Vinyals, Gemma and Martín-Sanchez, Vicente and Gómez-Acebo, Inés and Guevara, Marcela and Tardón, Adonina and Pérez-Gómez, Beatriz and Amiano, Pilar and Moreno, Victor and Molina, Antonio J. and Alonso-Molero, Jéssica and Moreno-Iribas, Conchi and Kogevinas, Manolis and Pollán, Marina and Llorca, Javier},
}