@misc{10481/51224,
year = {2018},
month = {1},
url = {http://hdl.handle.net/10481/51224},
abstract = {Herein, we describe the synthesis and application
of cross-linked polystyrene-based dual-function nano- and
microparticles containing both fluorescent tags and metals.
Despite containing a single dye, these particles exhibit a
characteristic dual-band fluorescence emission. Moreover,
these particles can be combined with different metal ions to
obtain hybrid metallofluorescent particles. We demonstrate
that these particles are easily nanofected into living cells,
allowing them to be used for effective fingerprinting in
multimodal fluorescence-based and mass spectrometry-based
flow cytometry experiments. Likewise, the in situ reductions of
the metal ions enable other potential uses of the particles as
heterogeneous catalysts.},
organization = {This work was funded by the Consejeria de Economia,
Innovacion, Ciencia y Empleo (Junta de Andalucia, grant
BIO-1778), the Spanish Ministry of Economy and Competitiveness
(grants BIO2016-80519-R and CTQ2014-56370-R)
and the Fundación Ramón Areces. A.D.-G. acknowledges
scholarships from the Spanish Ministry of Education (grant
FPU14/02181) and the University of Granada, PhD programme
in Biomedicine. T.V. thanks the Talentia Postdoc
Fellowship Programme (grant 267226, co-funded by the
Andalusian Knowledge Agency and the 7th Framework
Program of the European Union). A.U.-B. is grateful to the
EPSRC (EP/N021134/1) for funding. The authors thank the
staff at the microscopy facility of the Centre for Integrative
Biology (CIBIO) of the University of Trento (Italy), the staff at
the electron microscopy facilities of the Centre for Scientific
Instrumentation (CIC) of the University of Granada, and the
staff at the Flow Cytometry unit at the Pfizer-University of
Granada-Junta de Andalucia Centre for Genomics and
Oncological Research (GENYO).},
publisher = {American Chemical Society},
title = {Metallofluorescent Nanoparticles for Multimodal Applications},
doi = {10.1021/acsomega.7b01984},
author = {Delgado-Gonzalez, Antonio and García-Fernández, Emilio and Valero, Teresa and Cano-Cortés, Victoria and Ruedas Rama, María José and Unciti-Broceta, Asier and Sánchez Martín, Rosario María and Díaz Mochón, Juan José and Orte Gutiérrez, Ángel},
}