@misc{10481/50821,
year = {2018},
month = {2},
url = {http://hdl.handle.net/10481/50821},
abstract = {Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are
needed for the development of novel pain therapies. A genome-wide association study
implicated the 5p15.2 region in chronic widespread pain. This region includes the coding
region for FAM173B, a functionally uncharacterized protein. We demonstrate here that
FAM173B is a mitochondrial lysine methyltransferase that promotes chronic pain. Knockdown
and sensory neuron overexpression strategies showed that FAM173B is involved in
persistent inflammatory and neuropathic pain via a pathway dependent on its methyltransferase
activity. FAM173B methyltransferase activity in sensory neurons hyperpolarized
mitochondria and promoted macrophage/microglia activation through a reactive oxygen
species±dependent pathway. In summary, we uncover a role for methyltransferase activity
of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase
activity as a potential therapeutic target to treat debilitating chronic pain conditions.},
organization = {EMBO http://www.embo.org/funding-
awards/fellowships/short-term-fellowships (No
grant number available) received by HW. The
funder had no role in study design, data collection
and analysis, decision to publish, or preparation of
the manuscript. Boehringer Ingelheim Travel Grant
https://www.bifonds.de/fellowships-grants/travel-
grants.html (No grant number available) received by HW. The funder had no role in study design,
data collection and analysis, decision to publish, or
preparation of the manuscript. Utrecht University
Life Science Seed Grant https://www.uu.nl/en/
research/life-sciences/research/seed-grants (No
grant number available) received by NE. The funder
had no role in study design, data collection and
analysis, decision to publish, or preparation of the
manuscript.},
publisher = {Public Library of Science (PLOS)},
title = {Identification of FAM173B as a protein methyltransferase promoting chronic pain},
doi = {https://doi.org/10.1371/ journal.pbio.2003452},
author = {Willemen, Hanneke L.D.M. and González-Cano, Rafael},
}