@misc{10481/50334,
year = {2018},
month = {3},
url = {http://hdl.handle.net/10481/50334},
abstract = {The aim of this study was to evaluate the effectiveness of different nanoparticles-based solutions for dentin permeability reduction and to determine the viscoelastic performance of cervical dentin after their application. Four experimental nanoparticle solutions based on zinc, calcium or doxycycline-loaded polymeric nanoparticles (NPs) were applied on citric acid etched dentin, to facilitate the occlusion and the reduction of the fluid flow at the dentinal tubules.  After 24 h and 7 d of storage, cervical dentin was evaluated for fluid filtration. Field emission scanning electron microscopy, energy dispersive analysis, AFM and Nano-DMA analysis were also performed. Complex, storage, loss modulus and tan delta (δ) were assessed. Doxycycline-loaded NPs impaired tubule occlusion and fluid flow reduction trough dentin. Tubules were 100% occluded in dentin treated with calcium-loaded NPs or zinc-loaded NPs, analyzed at 7 d. Dentin treated with both zinc-NPs and calcium-NPs attained the highest reduction of dentinal fluid flow. Moreover, when treating dentin with zinc-NPs, complex modulus values attained at intertubular and peritubular dentin were higher than those obtained after applying calcium-NPs. Zinc-NPs are then supposed to fasten active dentin remodeling, with increased maturity and high mechanical properties. Zinc-based nanoparticles are then proposed for effective dentin remineralization and tubular occlusion. Further research to finally prove for clinical benefits in patients with dentin hypersensitivity using Zn-doped nanoparticles is encouraged.},
organization = {This work was supported by the Ministry of Economy and Competitiveness (MINECO) and European Regional Development Fund (FEDER) [Project MAT2017-85999-P]},
keywords = {cervical dentin},
keywords = {hypersensitivity},
keywords = {DMA},
keywords = {nanoparticles},
title = {Improved reactive nanoparticles to treat dentin hypersensitivity.},
doi = {10.1016/j.actbio.2018.03.033.},
author = {Toledano Osorio, Manuel and Osorio Ruiz, María Estrella and Sánchez Aguilera, Fátima and Medina Castillo, Antonio Luis and Osorio Ruiz, Raquel and Toledano Pérez, Manuel},
}