@misc{10481/49956,
year = {2016},
url = {http://hdl.handle.net/10481/49956},
abstract = {Background: Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with
offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and
their offspring are warranted.
Methods: In an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers
were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79),
and healthy normal weight controls (n:132). We assessed maternal growth and nutritional biomarkers at 24 weeks
(n = 269), 34 weeks (n = 310) and at delivery (n = 310) and the perinatal characteristics including cord blood
biomarkers.
Results: Obese and GD mothers had significantly lower weight gain during pregnancy and infant birth weight,
waist circumference, and placental weight were higher in the obese group, including a significantly increased
prevalence of macrosomia. Except for differences in markers of glucose metabolism (glucose, HbA1c, insulin and
uric acid) we found at some measures that overweight and/or obese mothers had lower levels of transferrin
saturation, hemoglobin, Vitamin B12 and folate and higher levels of C-reactive protein, erythrocyte sedimentation
rate, ferritin, and cortisol. GD mothers had similar differences in hemoglobin and C-reactive protein but higher
levels of folate. The latter was seen also in cord blood.
Conclusions: We identified several metabolic alterations in overweight, obese and GD mothers compared to
controls. Together with the observed differences in infant anthropometrics, these may be important biomarkers in
future research regarding the programming of health and disease in children.
Trial registration: The trial was registered at clinicaltrials.gov, identifier (NCT01634464).},
organization = {This
study was granted by Spanish Ministry of Innovation and Science. Junta de
Andalucía: Excellence Projects (P06-CTS-02341); Spanish Ministry of Economy
and Competitiveness (BFU2012-40254-C03-01); Research post-doctoral fellowship
from the Alfonso Martín Escudero Foundation; MyNewGut FP7 EU Project
(Grant agreement n° 613979); DynaHEALTH EU Project HORIZON 2020 (Grant
agreement n°: 633595-2); Marie Curie post-doctoral fellowship (FP7, no. 329812,
NutriOmics); The first author received Post Doc scholarships from Henning and
Johan Throne-Holst’s foundation, and the Swedish Research Council for Health,
Working life and Welfare (FORTE, ref 2014–2648).},
publisher = {Biomed Central},
keywords = {Pregnancy},
keywords = {Maternal overweight},
keywords = {Maternal obesity},
keywords = {Gestational diabetes},
keywords = {Offspring},
keywords = {Fetal nutrition},
keywords = {Early programming},
keywords = {Vitamin B12},
keywords = {Folate},
keywords = {Iron status},
keywords = {Glucose metabolism},
title = {Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)},
doi = {10.1186/s12889-016-2809-3},
author = {Berglund, Staffan K. and García-Valdés, Luz and Torres-Espínola, Francisco J. and Segura, María Teresa and Martínez-Zaldivar Moreno, Cristina and Aguilar Cordero, María José and Agil Abdalla, Mhmad Ahmad and Lorente Acosta, José Antonio and Florido Navio, Jesús and Padilla Vinuesa, María del Carmen and Altmae, Signe and Marcos, Ascensión and López-Sabater, María del Carmen and Campoy Folgoso, Cristina},
}