@misc{10481/49221,
year = {2018},
month = {1},
url = {http://hdl.handle.net/10481/49221},
abstract = {Here we report the synthesis and structural characterization of novel iron nanoparticles (FeNPs)-based short-peptide supramolecular hydrogels. These hybrid hydrogels composed of Fmoc-diphenylalanine (Fmoc-FF) peptide and FeNPs were prepared through the self-assembly of Fmoc-FF in a suspension containing FeNPs in the presence or absence of an external magnetic field. Optical images of these hydrogels revealed the formation of FeNPs column-like aggregates when the gels were formed in the presence of a magnetic field. Moreover, the intrincated structure derived from the interwoven of the fiber peptides with these FeNPs column-like aggregates resulted in anisotropic materials, more rigid under shears applied perpendicularly to the direction of the aggregates, presenting under these conditions values of G´ (storage modulus) about 7 times compared to native hydrogel. To the best of our knowledge this is the first example in which the mechanical properties of peptide hydrogels were strongly enhanced due to the presence of FeNPs. A theoretical model trying to explain this fenomenon is presented. Quite interesting CD, FTIR and synchrotron X-ray difraction analysis indicated that the anti-parallel -sheet arrangement of Fmoc-FF peptide was highly conserved in the hydrogels containing FeNPs. Moreover, FLCS measurements showed that the diffusion of a small solute through the hydrogel network was improved in hydrogels containing FeNPs probably caused by the formation of preferential channels for diffusion. Taken together, our results provide a new method for the synthesis of novel hybrid Fmoc-FF-FeNPs anisotropic hydrogels with enhanced mechanical strength and water-like diffusion behavior, thus easing their application in drug delivery and tissue engineering.},
organization = {This study was supported by projects CTQ-2014-53598-R and FIS2013-41821-R (Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, MINECO (Spain), co-funded by ERDF, European Union), FIS2017-85954-R (Agencia 
Estatal de Investigación, AEI, Spain, co-funded by Fondo Europeo de Desarrollo Regional, ERDF, European Union) and by Junta de Andalucía (Spain) project P12-FQM-2721.},
publisher = {Royal Society of Chemistry},
keywords = {Iron nanoparticles},
keywords = {Hydrogels},
title = {Iron Nanoparticles-Based Supramolecular Hydrogels to Originate Anisotropic Hybrid Materials with Enhanced Mechanical Strength},
doi = {10.1039/C7QM00573C},
author = {Contreras-Montoya, Rafael and Bonhome Espinosa, Ana Belén and Orte Gutiérrez, Ángel and Miguel, Delia and Delgado-López, José M. and García López-Durán, Juan De Dios and Cuerva Carvajal, Juan Manuel and López López, Modesto Torcuato and Álvarez Cienfuegos Rodríguez, Luis},
}